Abstract
An 86-year-old woman underwent a cholecystectomy for gallbladder cancer. Seven months later, an abdominal CT scan showed multiple liver and lymph node metastases. Treatment with S-1 was started at a dose of 100 mg/day, but was changed to alternate-day administration because of diarrhea. Metastatic lesions showed a complete response after 7 months of chemotherapy. S-1 alternate-day therapy could be maintained without any severe adverse events. This method can be managed safely and with certainty in an elderly patient and it has demonstrated efficacy in the treatment of recurrent gallbladder cancer.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Aged, 80 and over
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Antimetabolites, Antineoplastic / administration & dosage
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Antimetabolites, Antineoplastic / therapeutic use*
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Drug Combinations
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Female
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Gallbladder Neoplasms / drug therapy*
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Gallbladder Neoplasms / pathology
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Gallbladder Neoplasms / surgery
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Humans
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Liver Neoplasms / drug therapy*
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Liver Neoplasms / secondary
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Lymphatic Metastasis
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Oxonic Acid / administration & dosage
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Oxonic Acid / therapeutic use*
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Recurrence
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Tegafur / administration & dosage
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Tegafur / therapeutic use*
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Treatment Outcome
Substances
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Antimetabolites, Antineoplastic
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Drug Combinations
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S 1 (combination)
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Tegafur
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Oxonic Acid