Can a bleaching toothpaste containing Blue Covarine demonstrate the same bleaching as conventional techniques? An in vitro, randomized and blinded study

J Appl Oral Sci. 2015 Nov-Dec;23(6):609-13. doi: 10.1590/1678-775720150268.

Abstract

Objective: The purpose of this in vitro study was to compare the efficacy of a bleaching toothpaste containing Blue Covarine vs. conventional tooth bleaching techniques using peroxides (both in-office and at-home).

Material and methods: Samples were randomly distributed into five experimental groups (n=15): C - Control; BC - Bleaching toothpaste containing Blue Covarine; WBC - Bleaching toothpaste without Blue Covarine; HP35 - In-office bleaching using 35% hydrogen peroxide; and CP10 - At-home bleaching with 10% carbamide peroxide. The dental bleaching efficacy was determined by the color difference (ΔE), luminosity (ΔL), green-red axis (Δa), and blue-yellow axis (Δb). The CIELab coordinates were recorded with reflectance spectroscopy at different times: T0 - baseline, T1 - immediately after bleaching, T2 - 7 days, T3 - 14 days, and T4 - 21 days after the end of treatments. Data were analyzed by a repeated measures mixed ANOVA and post hoc Bonferroni test, with a significance level of 5%.

Results: No significant differences were found between the treatment groups C, BC, and WBC. The groups HP35 and CP10 showed significantly higher whitening efficacy than groups C, BC, and WBC.

Conclusions: There were no significant differences in the whitening efficacy between a Blue Covarine containing toothpaste, a standard whitening toothpaste, and a control. Neither of the whitening toothpastes tested were as effective as in-office or at-home bleaching treatments.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Carbamide Peroxide
  • Color
  • Colorimetry
  • Humans
  • Hydrogen Peroxide / chemistry
  • Isoindoles / chemistry*
  • Metalloporphyrins / chemistry*
  • Peroxides / chemistry
  • Reference Values
  • Reproducibility of Results
  • Single-Blind Method
  • Spectrophotometry
  • Statistics, Nonparametric
  • Time Factors
  • Tooth Bleaching / methods*
  • Tooth Bleaching Agents / chemistry*
  • Toothbrushing
  • Toothpastes / chemistry*
  • Urea / analogs & derivatives
  • Urea / chemistry

Substances

  • Isoindoles
  • Metalloporphyrins
  • Peroxides
  • Tooth Bleaching Agents
  • Toothpastes
  • blue covarine
  • Carbamide Peroxide
  • Urea
  • Hydrogen Peroxide