Determinants of epoxy allergy in the construction industry: a case-control study

Contact Dermatitis. 2016 May;74(5):259-66. doi: 10.1111/cod.12529. Epub 2016 Jan 29.

Abstract

Background: Workers exposed to epoxy products are at risk of developing allergic contact dermatitis.

Objectives: To compare workers throughout the German construction industry with and without skin allergy to epoxy resins, hardeners, and/or reactive diluents, and to investigate which determinants are related to the development of epoxy allergy.

Methods: A questionnaire was completed by 179 epoxy allergy cases, and 151 epoxy workers as controls. Crude and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by the use of backwards stepwise logistic regression analysis. A multiple imputation approach was used to deal with missing data.

Results: Epoxy allergy was associated with an unusually high level of exposure to epoxy products [OR 2.13 (95%CI: 1.01-4.51)], wearing short sleeves or short trousers [OR 2.38 (95%CI: 1.03-5.52)], and not always using the correct type of gloves [OR 2.12 (95%CI: 1.12-4.01)]. A monotonic increasing risk was found with increasing exposure hours per week [OR 1.72 (95%CI: 1.39-2.14)]. Not using skin cream was inversely associated with epoxy allergy [OR 0.22 (95%CI: 0.08-0.59)]. Years working with epoxy products were inversely associated with epoxy allergy [OR 0.41 (95%CI: 0.27-0.61) per 10-year increase], suggesting a healthy worker survivor effect.

Conclusions: Occupational epoxy allergy may be prevented by improving occupational hygiene behaviour and personal protection.

Keywords: epidemiology; occupational; occupational hygiene behaviour; prevention.

MeSH terms

  • Adult
  • Case-Control Studies
  • Construction Industry*
  • Dermatitis, Allergic Contact / epidemiology*
  • Dermatitis, Allergic Contact / etiology
  • Dermatitis, Occupational / epidemiology*
  • Dermatitis, Occupational / etiology
  • Epoxy Resins / adverse effects*
  • Germany / epidemiology
  • Gloves, Protective / statistics & numerical data*
  • Hand Dermatoses / epidemiology*
  • Hand Dermatoses / etiology
  • Humans
  • Logistic Models
  • Middle Aged
  • Odds Ratio
  • Protective Clothing / statistics & numerical data*
  • Surveys and Questionnaires

Substances

  • Epoxy Resins