Is Aerosolized Pentamidine for Pneumocystis Pneumonia Prophylaxis in Renal Transplant Recipients Not as Safe as We Might Think?

N Macesic; K Urbancic; F Ierino; M L Grayson

doi:10.1128/AAC.02290-15

Is Aerosolized Pentamidine for Pneumocystis Pneumonia Prophylaxis in Renal Transplant Recipients Not as Safe as We Might Think?

Antimicrob Agents Chemother. 2016 Mar 25;60(4):2502-4. doi: 10.1128/AAC.02290-15. Print 2016 Apr.

Authors

N Macesic¹, K Urbancic², F Ierino³, M L Grayson⁴

Affiliations

¹ Department of Infectious Diseases, Austin Health, Melbourne, Australia Division of Infectious Diseases, Columbia University Medical Center, New York, New York, USA [email protected] [email protected].
² Department of Infectious Diseases, Austin Health, Melbourne, Australia.
³ Department of Nephrology, Austin Health, Melbourne, Australia Department of Medicine, University of Melbourne, Melbourne, Australia.
⁴ Department of Infectious Diseases, Austin Health, Melbourne, Australia Department of Medicine, University of Melbourne, Melbourne, Australia [email protected] [email protected].

Abstract

Outbreaks ofPneumocystispneumonia have been described in renal transplant recipients. Aerosolized pentamidine is frequently used for prophylaxis in this setting. We report our experience with aerosolized pentamidine use in 56 renal transplant recipients. We found high rates of adverse reactions in patients with chronic respiratory disease.

MeSH terms

Adult
Aerosols
Antifungal Agents / administration & dosage
Antifungal Agents / adverse effects*
Bronchial Spasm / chemically induced
Bronchial Spasm / physiopathology
Female
Humans
Kidney Transplantation*
Lung / drug effects
Lung / physiopathology
Male
Pentamidine / administration & dosage
Pentamidine / adverse effects*
Pneumocystis / drug effects
Pneumocystis / physiology
Pneumonia, Pneumocystis / microbiology
Pneumonia, Pneumocystis / prevention & control*
Renal Insufficiency, Chronic / pathology
Renal Insufficiency, Chronic / surgery
Respiratory Tract Diseases / physiopathology*
Transplant Recipients
Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use*

Substances

Aerosols
Antifungal Agents
Pentamidine
Trimethoprim, Sulfamethoxazole Drug Combination