Lanostane-type triterpenes from the fungal endophyte Scleroderma UFSMSc1 (Persoon) Fries

Bioorg Med Chem Lett. 2016 Feb 15;26(4):1173-6. doi: 10.1016/j.bmcl.2016.01.044. Epub 2016 Jan 18.

Abstract

Two lanostane triterpenoids (sclerodols A and B) were isolated from the culture of the Eucalyptus grandis derived from the endophyte Scleroderma UFSM Sc1(Persoon) Fries together with three known compounds: one related triterpenoid lanosta-8,23-dien-3β,25-diol, the disaccharide α,β-trehalose, and the sugar alcohol mannitol. Their structures were elucidated on the basis of 2D NMR, HRME, and single-crystal X-ray diffraction data. The methanol crude extract and the isolated lanostane triterpenoids showed promising anticandidal activities.

Keywords: Anticandidal activity; Fungal endophyte; Lanostenoids; Scleroderma UFSMSc1 (Persoon) Fries.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / chemistry*
  • Antifungal Agents / isolation & purification
  • Antifungal Agents / pharmacology
  • Basidiomycota / metabolism*
  • Candida / drug effects
  • Crystallography, X-Ray
  • Eucalyptus / microbiology
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Molecular Conformation
  • Triterpenes / chemistry*
  • Triterpenes / isolation & purification
  • Triterpenes / pharmacology

Substances

  • Antifungal Agents
  • Triterpenes
  • sclerodol A
  • sclerodol B