A meta-analysis of low-molecular-weight heparin to prevent pregnancy loss in women with inherited thrombophilia

Blood. 2016 Mar 31;127(13):1650-5. doi: 10.1182/blood-2015-12-626739. Epub 2016 Feb 2.

Abstract

We performed a meta-analysis of randomized controlled trials comparing low-molecular-weight heparin (LMWH) vs no LMWH in women with inherited thrombophilia and prior late (≥10 weeks) or recurrent early (<10 weeks) pregnancy loss. Eight trials and 483 patients met our inclusion criteria. There was no significant difference in livebirth rates with the use of LMWH compared with no LMWH (relative risk, 0.81; 95% confidence interval, 0.55-1.19;P= .28), suggesting no benefit of LMWH in preventing recurrent pregnancy loss in women with inherited thrombophilia.

Publication types

  • Case Reports
  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Abortion, Habitual / epidemiology
  • Abortion, Habitual / prevention & control*
  • Adult
  • Female
  • Heparin, Low-Molecular-Weight / therapeutic use*
  • Humans
  • Pregnancy
  • Pregnancy Complications, Hematologic / drug therapy*
  • Pregnancy Complications, Hematologic / epidemiology
  • Thrombophilia / drug therapy*
  • Thrombophilia / epidemiology

Substances

  • Heparin, Low-Molecular-Weight

Supplementary concepts

  • Thrombophilia, hereditary