Spindle cell oncocytoma of adenohypophysis: Report of a case and immunohistochemical review of literature

Pathol Res Pract. 2016 Mar;212(3):222-5. doi: 10.1016/j.prp.2015.07.014. Epub 2015 Sep 8.

Abstract

We present a case of spindle cell oncocytoma (SCO) of the adenohypophysis in a 70-year-old Vietnamese male. The patient was admitted to Cho Ray Hospital after suffering from headache and visual disturbance for 6 months. Clinicians detected a 60×55×45 mm(3) mass located in the suprasellar-sellar region. Histopathologically, the resected tumor was composed of spindle cells with oncocytic appearance. Immunohistochemical examination revealed expression of anti-mitochondria antibody (AMA), vimentin, thyroid transcription factor 1 (TTF-1), epithelial membrane antigen (EMA) and galectin-3. These histologic and immunohistochemical findings are suggestive of SCO.

Keywords: Immunohistochemistry; Mitochondria; Sellar neoplasms; Spindle cell oncocytoma.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adenoma, Oxyphilic / pathology*
  • Aged
  • Biomarkers, Tumor / analysis
  • Humans
  • Immunohistochemistry
  • Male
  • Pituitary Gland, Anterior / pathology
  • Pituitary Neoplasms / pathology*

Substances

  • Biomarkers, Tumor