Evaluation of Polymorphic Locus Sequence Typing for Candida glabrata Epidemiology

J Clin Microbiol. 2016 Apr;54(4):1042-50. doi: 10.1128/JCM.03106-15. Epub 2016 Feb 3.

Abstract

The opportunistic yeast Candida glabratais increasingly refractory to antifungal treatment or prophylaxis and relatedly is increasingly implicated in health care-associated infections. To elucidate the epidemiology of these infections, strain typing is required. Sequence-based typing provides multiple advantages over length-based methods, such as pulsed-field gel electrophoresis (PFGE); however, conventional multilocus sequence typing (targeting 6 conserved loci) and whole-genome sequencing are impractical for routine use. A commercial sequence-based typing service for C. glabratathat targets polymorphic tandem repeat-containing loci has recently been developed. These CgMT-J and CgMT-M services were evaluated with 56 epidemiologically unrelated isolates, 4 to 7 fluconazole-susceptible or fluconazole-resistant isolates from each of 5 center A patients, 5 matched pairs of fluconazole-susceptible/resistant isolates from center B patients, and 7 isolates from a center C patient who responded to then failed caspofungin therapy. CgMT-J and CgMT-M generated congruent results, resolving isolates into 24 and 20 alleles, respectively. Isolates from all but one of the center A patients shared the same otherwise rare alleles, suggesting nosocomial transmission. Unexpectedly, Pdr1 sequencing showed that resistance arose independently in each patient. Similarly, most isolates from center B also clustered together; however, this may reflect a dominant clone since their alleles were shared by multiple unrelated isolates. Although distinguishable by their echinocandin susceptibilities, all isolates from the center C patient shared alleles, in agreement with the previously reported relatedness of these isolates based on PFGE. Finally, we show how phylogenetic clusters can be used to provide surrogate parents to analyze the mutational basis for antifungal resistance.

Publication types

  • Evaluation Study
  • Multicenter Study

MeSH terms

  • Candida glabrata / classification*
  • Candida glabrata / genetics*
  • Candida glabrata / isolation & purification
  • Candidiasis / epidemiology*
  • Candidiasis / microbiology*
  • Cluster Analysis
  • Genetic Loci
  • Genetic Variation
  • Genotype
  • Humans
  • Molecular Epidemiology / methods
  • Multilocus Sequence Typing / methods*
  • Mycological Typing Techniques / methods*

Grants and funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.