Janus Silver-Mesoporous Silica Nanocarriers for SERS Traceable and pH-Sensitive Drug Delivery in Cancer Therapy

ACS Appl Mater Interfaces. 2016 Feb;8(7):4303-8. doi: 10.1021/acsami.5b11310. Epub 2016 Feb 9.

Abstract

A facile and cheap strategy was used to fabricate the novel Janus silver-mesoporous silica nanoparticles with excellent SPR and mesoporous properties for simultaneous SERS imaging and pH-responsive drug release, leading to the efficient cancer theranostic with less toxic effects.

Keywords: Janus; SERS; cancer therapy; selective; silver mesoporous silica.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Doxorubicin / administration & dosage*
  • Doxorubicin / chemistry
  • Drug Delivery Systems*
  • Gold / chemistry
  • HeLa Cells
  • Hep G2 Cells
  • Humans
  • Nanoparticles / administration & dosage*
  • Nanoparticles / chemistry
  • Neoplasms / diagnostic imaging
  • Neoplasms / drug therapy*
  • Neoplasms / pathology
  • Silicon Dioxide / chemistry
  • Silver / chemistry
  • Spectrum Analysis, Raman
  • Surface Plasmon Resonance

Substances

  • Silver
  • Gold
  • Silicon Dioxide
  • Doxorubicin