Expanding the Range of Protein Function at the Far End of the Order-Structure Continuum

J Biol Chem. 2016 Mar 25;291(13):6706-13. doi: 10.1074/jbc.R115.692590. Epub 2016 Feb 5.

Abstract

The traditional view of the structure-function paradigm is that a protein's function is inextricably linked to a well defined, three-dimensional structure, which is determined by the protein's primary amino acid sequence. However, it is now accepted that a number of proteins do not adopt a unique tertiary structure in solution and that some degree of disorder is required for many proteins to perform their prescribed functions. In this review, we highlight how a number of protein functions are facilitated by intrinsic disorder and introduce a new protein structure taxonomy that is based on quantifiable metrics of a protein's disorder.

Keywords: biophysics; conformational change; intrinsically disordered protein; protein folding; protein structure.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Amino Acids / chemistry*
  • Amino Acids / metabolism
  • CREB-Binding Protein / chemistry*
  • CREB-Binding Protein / genetics
  • CREB-Binding Protein / metabolism
  • Colicins / chemistry*
  • Colicins / genetics
  • Colicins / metabolism
  • Escherichia coli / genetics
  • Escherichia coli / metabolism
  • Eukaryotic Initiation Factors / chemistry*
  • Eukaryotic Initiation Factors / genetics
  • Eukaryotic Initiation Factors / metabolism
  • Humans
  • Intrinsically Disordered Proteins / chemistry*
  • Intrinsically Disordered Proteins / genetics
  • Intrinsically Disordered Proteins / metabolism
  • Protein Binding
  • Protein Folding
  • Protein Interaction Domains and Motifs
  • Protein Structure, Secondary
  • Structure-Activity Relationship
  • Thermodynamics

Substances

  • Amino Acids
  • Colicins
  • EIF4EBP2 protein, human
  • Eukaryotic Initiation Factors
  • Intrinsically Disordered Proteins
  • immE9 protein, E coli
  • CREB-Binding Protein
  • CREBBP protein, human

Associated data

  • PDB/1bh4
  • PDB/1jjs
  • PDB/1k7b
  • PDB/1kbh
  • PDB/1qjp
  • PDB/1ujw
  • PDB/1zoq
  • PDB/2c52
  • PDB/2ivz
  • PDB/2k3g
  • PDB/2k3j
  • PDB/2kac
  • PDB/2kkj
  • PDB/2l14
  • PDB/2mx4
  • PDB/3O0e
  • PDB/3am7