Deregulation of HOX genes by DNMT3A and MLL mutations converges on BMI1

Leukemia. 2016 Jul;30(7):1609-12. doi: 10.1038/leu.2016.15. Epub 2016 Feb 8.

Authors

Y-T Tan¹, Y Sun¹, S-H Zhu¹, L Ye², C-J Zhao¹, W-L Zhao¹, Z Chen¹, S-J Chen¹, H Liu¹

Affiliations

¹ State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, School of Medicine and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Collaborative Innovation Center of Systems Biomedicine, Collaborative Innovation Center of Hematology, Shanghai, China.
² Department of Medicine, Institute for Human Genetics, University of California, San Francisco, CA, USA.

PMID: 26854025
DOI: 10.1038/leu.2016.15

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line, Tumor
DNA (Cytosine-5-)-Methyltransferases / genetics*
DNA Methyltransferase 3A
Gene Expression Regulation, Leukemic / physiology*
Genes, Homeobox / genetics*
Humans
Leukemia, Myeloid, Acute / genetics*
Mice
Mutation
Myeloid-Lymphoid Leukemia Protein / genetics*
Polycomb Repressive Complex 1 / genetics*

Substances

DNMT3A protein, human
Dnmt3a protein, mouse
Myeloid-Lymphoid Leukemia Protein
DNA (Cytosine-5-)-Methyltransferases
DNA Methyltransferase 3A
Polycomb Repressive Complex 1