Simultaneous mapping of water shift and B₁ (WASABI)-Application to field-Inhomogeneity correction of CEST MRI data

Purpose: Together with the development of MRI contrasts that are inherently small in their magnitude, increased magnetic field accuracy is also required. Hence, mapping of the static magnetic field (B₀ ) and the excitation field (B₁ ) is not only important to feedback shim algorithms, but also for postprocess contrast-correction procedures.

Methods: A novel field-inhomogeneity mapping method is presented that allows simultaneous mapping of the water shift and B₁ (WASABI) using an off-resonant rectangular preparation pulse. The induced Rabi oscillations lead to a sinc-like spectrum in the frequency-offset dimension and allow for determination of B₀ by its symmetry axis and of B₁ by its oscillation frequency.

Results: Stability of the WASABI method with regard to the influences of T₁ , T₂ , magnetization transfer, and repetition time was investigated and its convergence interval was verified. B₀ and B₁ maps obtained simultaneously by means of WASABI in the human brain at 3 T and 7 T can compete well with maps obtained by standard methods. Finally, the method was applied successfully for B₀ and B₁ correction of chemical exchange saturation transfer MRI (CEST-MRI) data of the human brain.

Conclusion: The proposed WASABI method yields a novel simultaneous B₀ and B₁ mapping within 1 min that is robust and easy to implement. Magn Reson Med 77:571-580, 2017. © 2016 International Society for Magnetic Resonance in Medicine.