A Mechanism for Somatic Brain Mosaicism

Irving L Weissman; Fred H Gage

doi:10.1016/j.cell.2016.01.048

A Mechanism for Somatic Brain Mosaicism

Cell. 2016 Feb 11;164(4):593-5. doi: 10.1016/j.cell.2016.01.048.

Authors

Irving L Weissman¹, Fred H Gage²

Affiliations

¹ Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford University, Palo Alto, CA 94305, USA. Electronic address: [email protected].
² The Salk Institute for Biological Studies, Laboratory of Genetics, La Jolla, CA 92037, USA. Electronic address: [email protected].

PMID: 26871622
DOI: 10.1016/j.cell.2016.01.048

Abstract

Double-strand break repair is required for neural development, and brain cells contain somatic genomic variations. Now, Wei et al. demonstrate that neural stem and progenitor cells undergo very frequent DNA breaks in a very restricted set of genes involved in neural cell adhesion and synapse function.

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MeSH terms

Animals
DNA Breaks*
Humans
Neural Stem Cells / metabolism*