A New Way to Diversify Antibodies by DNA Transposition

Davide F Robbiani; Michel C Nussenzweig

doi:10.1016/j.cell.2016.01.031

A New Way to Diversify Antibodies by DNA Transposition

Cell. 2016 Feb 11;164(4):601-2. doi: 10.1016/j.cell.2016.01.031.

Authors

Davide F Robbiani¹, Michel C Nussenzweig²

Affiliations

¹ Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10065, USA. Electronic address: [email protected].
² Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10065, USA; Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10065, USA. Electronic address: [email protected].

PMID: 26871626
DOI: 10.1016/j.cell.2016.01.031

Abstract

While searching for new therapeutics against malaria, Lanzavecchia and colleagues discovered that antibodies can be diversified by DNA sequences encoded outside of antibody genes.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Antibodies, Monoclonal / immunology*
Antibody Specificity*
Antigenic Variation / immunology*
Antigens, Protozoan / immunology*
Humans
Malaria / immunology*
Mutagenesis, Insertional / genetics*
Plasmodium falciparum / immunology*
Receptors, Immunologic / immunology*

Substances

Antibodies, Monoclonal
Antigens, Protozoan
Receptors, Immunologic

Abstract

Publication types

MeSH terms

Substances

Grants and funding