High-flow nasal cannula oxygen therapy for acute exacerbation of interstitial pneumonia: A case series

Yukihiro Horio; Takahisa Takihara; Kyoko Niimi; Masamichi Komatsu; Masako Sato; Jun Tanaka; Hiroto Takiguchi; Hiromi Tomomatsu; Katsuyoshi Tomomatsu; Naoki Hayama; Tsuyoshi Oguma; Takuya Aoki; Tetsuya Urano; Atsushi Takagi; Koichiro Asano

doi:10.1016/j.resinv.2015.09.005

High-flow nasal cannula oxygen therapy for acute exacerbation of interstitial pneumonia: A case series

Respir Investig. 2016 Mar;54(2):125-9. doi: 10.1016/j.resinv.2015.09.005. Epub 2015 Nov 19.

Authors

Yukihiro Horio¹, Takahisa Takihara², Kyoko Niimi³, Masamichi Komatsu⁴, Masako Sato⁵, Jun Tanaka⁶, Hiroto Takiguchi⁷, Hiromi Tomomatsu⁸, Katsuyoshi Tomomatsu⁹, Naoki Hayama¹⁰, Tsuyoshi Oguma¹¹, Takuya Aoki¹², Tetsuya Urano¹³, Atsushi Takagi¹⁴, Koichiro Asano¹⁵

Affiliations

¹ Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: [email protected].
² Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: [email protected].
³ Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: [email protected].
⁴ Division of General Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: [email protected].
⁵ Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: [email protected].
⁶ Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: [email protected].
⁷ Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: [email protected].
⁸ Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: [email protected].
⁹ Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: [email protected].
¹⁰ Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: [email protected].
¹¹ Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: [email protected].
¹² Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: [email protected].
¹³ Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: [email protected].
¹⁴ Division of General Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: [email protected].
¹⁵ Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: [email protected].

PMID: 26879483
DOI: 10.1016/j.resinv.2015.09.005

Abstract

We report 3 cases (all men, age: 69-81 years) of acute exacerbation of interstitial pneumonia (AEIP) that were successfully treated with a high-flow nasal cannula (HFNC), which delivers heated, humidified gas at a fraction of inspired oxygen (FIO2) up to 1.0 (100%). Oxygenation was insufficient under non-rebreathing face masks; however, the introduction of HFNC with an FIO2 of 0.7-1.0 (flow rate: 40 L/min) improved oxygenation and was well-tolerated until the partial pressure of oxygen in blood/FIO2 ratio increased (between 21 and 26 days). Thus, HFNC might be an effective and well-tolerated therapeutic addition to the management of AEIP.

Keywords: Acute exacerbation; Acute respiratory failure; High-flow nasal cannula; Interstitial pneumonia; Oxygen therapy.

Publication types

Case Reports

MeSH terms

Acute Disease
Aged
Aged, 80 and over
Cannula*
Disease Progression
Humans
Lung Diseases, Interstitial / therapy*
Male
Oxygen Inhalation Therapy / instrumentation*
Oxygen Inhalation Therapy / methods*
Treatment Outcome