TLRs of Our Fathers

Mihai G Netea; Leo A B Joosten

doi:10.1016/j.immuni.2016.02.003

TLRs of Our Fathers

Immunity. 2016 Feb 16;44(2):218-20. doi: 10.1016/j.immuni.2016.02.003.

Authors

Mihai G Netea¹, Leo A B Joosten²

Affiliations

¹ Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands. Electronic address: [email protected].
² Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands.

PMID: 26885854
DOI: 10.1016/j.immuni.2016.02.003

Abstract

Two new studies published in The American Journal of Human Genetics (Dannemann et al., 2016; Deschamps et al., 2016) show that introgression of innate immune genes from Neandertals and Denisovans contributed to the modern genome of European and Asian, but not African, populations, and this might partly explain differences in susceptibility to immune-mediated diseases.

Publication types

Comment

MeSH terms

Adaptation, Physiological / genetics*
Animals
Haplotypes*
Humans
Immunity, Innate / genetics*
Neanderthals / genetics*
Neanderthals / immunology*
Toll-Like Receptors / genetics*

Substances

Toll-Like Receptors