1 Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Charité, University Medicine Berlin, Berlin, Germany Department of Biostatistics, Coordination Center for Clinical Trials, Charité, University Medicine Berlin, Berlin, Germany Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Charité, University Medicine Berlin, Berlin, Germany, [email protected].