Preventing ventriculostomy-related infections with antibiotic-impregnated drains in hospitals: a two-centre Dutch study

J D M Verberk; J W Berkelbach van der Sprenkel; M P Arts; P J W Dennesen; M J M Bonten; M S M van Mourik

doi:10.1016/j.jhin.2015.12.018

Preventing ventriculostomy-related infections with antibiotic-impregnated drains in hospitals: a two-centre Dutch study

J Hosp Infect. 2016 Apr;92(4):401-4. doi: 10.1016/j.jhin.2015.12.018. Epub 2016 Jan 21.

Authors

J D M Verberk¹, J W Berkelbach van der Sprenkel², M P Arts³, P J W Dennesen⁴, M J M Bonten⁵, M S M van Mourik⁶

Affiliations

¹ Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands.
² Department of Neurosurgery, University Medical Centre Utrecht, Utrecht, The Netherlands.
³ Department of Neurosurgery, Medisch Centrum Haaglanden, The Hague, The Netherlands.
⁴ Department of Intensive Care, Medisch Centrum Haaglanden, The Hague, The Netherlands.
⁵ Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands; Department of Medical Microbiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
⁶ Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands. Electronic address: [email protected].

PMID: 26895616
DOI: 10.1016/j.jhin.2015.12.018

Abstract

This observational cohort study assessed the effect of the introduction of antibiotic-impregnated external ventricular drains (AI-EVDs), as opposed to plain silicone EVDs, on the occurrence of ventriculostomy-related infections (VRIs) in two Dutch hospitals, with no other changes to their clinical practice. VRI was defined using the criteria of the Centers for Disease Control and Prevention, and with a culture-based definition. A propensity-score-adjusted competing risks survival analysis showed that introduction of AI-EVDs did not significantly decrease the risk of VRIs in routine care, nor affect the bacterial aetiology, even after adjustment for confounding and competing events.

Keywords: Antibiotic-impregnated; Competing risks; External ventricular drains; Neurosurgery; Survival; Ventriculostomy-related infection.

Publication types

Observational Study

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents / therapeutic use*
Cohort Studies
Drainage / methods*
Female
Hospitals
Humans
Male
Middle Aged
Netherlands
Surgical Wound Infection / epidemiology*
Surgical Wound Infection / prevention & control*
Treatment Outcome
Ventriculostomy / adverse effects*
Young Adult

Substances

Anti-Bacterial Agents