Ammonium tetrathiomolybdate as a water-soluble and slow-release hydrogen sulfide donor

Bioorg Med Chem Lett. 2016 Mar 15;26(6):1585-1588. doi: 10.1016/j.bmcl.2016.02.005. Epub 2016 Feb 4.

Abstract

Ammonium tetrathiomolybdate (TTM) was found to be a slow hydrogen sulfide (H2S) releasing agent. Its H2S generation capability in aqueous solutions was confirmed by UV-vis and fluorescence assays. TTM also showed H2S-like cytoprotective effects in hydrogen peroxide (H2O2)-induced oxidative damage in HaCaT cells.

Keywords: Ammonium tetrathiomolybdate; Donor; Hydrogen sulfide; Oxidative damage.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line
  • Cell Survival / drug effects
  • Dose-Response Relationship, Drug
  • Humans
  • Hydrogen Peroxide / pharmacology
  • Hydrogen Sulfide / chemistry*
  • Molecular Structure
  • Molybdenum / chemistry*
  • Molybdenum / pharmacology
  • Oxidation-Reduction / drug effects
  • Oxidative Stress / drug effects
  • Solubility / drug effects
  • Structure-Activity Relationship
  • Water / chemistry*

Substances

  • Water
  • Molybdenum
  • tetrathiomolybdate
  • Hydrogen Peroxide
  • Hydrogen Sulfide