Perenosins: a new class of anion transporter with anti-cancer activity

Org Biomol Chem. 2016 Mar 7;14(9):2645-50. doi: 10.1039/c6ob00002a.

Abstract

A new class of anion transporter named 'perenosins' consisting of a pyrrole linked through an imine to either an indole, benzimidazole or indazole is reported. The indole containing members of the perenosin family function as effective transmembrane Cl(-)/NO3(-) antiporters and HCl cotransporters in a manner similar to the prodigiosenes. The compounds reduce the viability of MDA-MB-231 and MCF-7.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anions / metabolism*
  • Antineoplastic Agents, Phytogenic / chemical synthesis
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Antiporters / chemical synthesis
  • Antiporters / chemistry
  • Antiporters / pharmacology*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Crystallography, X-Ray
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Humans
  • Imines / chemistry*
  • Indoles / chemistry
  • Indoles / pharmacology*
  • Ion Transport / drug effects
  • MCF-7 Cells
  • Models, Molecular
  • Molecular Structure
  • Pyrroles / chemical synthesis
  • Pyrroles / chemistry
  • Pyrroles / pharmacology*
  • Structure-Activity Relationship

Substances

  • Anions
  • Antineoplastic Agents, Phytogenic
  • Antiporters
  • Imines
  • Indoles
  • Pyrroles