The photodynamic activity occurring through the lysosome photo-damage is effective in terms of triggered synergic effects which can avoid chemo-resistance pathways. The potential photodynamic activity of two fluorescent lysosome-specific probes was studied providing their interaction with human serum albumin, demonstrating their in vitro generation of singlet oxygen and investigating the resulted photo-toxic effect in human cancer cells.
Keywords: Human serum albumin; Lysosomes; Photosensitizers; Reactive oxygen species; Singlet oxygen; Thiophene dyes.
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