Younger age at initiation of the human papillomavirus (HPV) vaccination series is associated with higher rates of on-time completion

Jennifer L St Sauver; Lila J Finney Rutten; Jon O Ebbert; Debra J Jacobson; Michaela E McGree; Robert M Jacobson

doi:10.1016/j.ypmed.2016.02.039

Younger age at initiation of the human papillomavirus (HPV) vaccination series is associated with higher rates of on-time completion

Prev Med. 2016 Aug:89:327-333. doi: 10.1016/j.ypmed.2016.02.039. Epub 2016 Feb 28.

Authors

Jennifer L St Sauver¹, Lila J Finney Rutten², Jon O Ebbert³, Debra J Jacobson⁴, Michaela E McGree⁴, Robert M Jacobson⁵

Affiliations

¹ Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street, Rochester, MN 55905, USA; Robert D and Patricia E Kern Center for the Science of Health Care Delivery, College of Medicine, Mayo Clinic, 200 First Street, Rochester, MN 55905, USA. Electronic address: [email protected].
² Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street, Rochester, MN 55905, USA; Robert D and Patricia E Kern Center for the Science of Health Care Delivery, College of Medicine, Mayo Clinic, 200 First Street, Rochester, MN 55905, USA.
³ Robert D and Patricia E Kern Center for the Science of Health Care Delivery, College of Medicine, Mayo Clinic, 200 First Street, Rochester, MN 55905, USA; Division of Primary Care Internal Medicine, Department of Medicine, Mayo Clinic, 200 First Street, Rochester, MN 55905, USA.
⁴ Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, 200 First Street, Rochester, MN 55905, USA; Robert D and Patricia E Kern Center for the Science of Health Care Delivery, College of Medicine, Mayo Clinic, 200 First Street, Rochester, MN 55905, USA.
⁵ Robert D and Patricia E Kern Center for the Science of Health Care Delivery, College of Medicine, Mayo Clinic, 200 First Street, Rochester, MN 55905, USA; Division of Community Pediatric and Adolescent Medicine, Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First Street, Rochester, MN 55905, USA.

Abstract

Vaccination rates for human papillomavirus (HPV) have remained disappointingly low. It is critical to identify methods to increase on-time vaccine series completion rates (before 13 or 15years). To determine whether younger age (9 to 10years of age) at HPV vaccine series initiation was associated with improved on-time completion rates compared to initiation at 11 to 12years, we examined the prevalence of on-time HPV vaccine series completion rates from August 2006 through December 2012 in a large, population-based cohort of children and adolescents (aged 9.5 to 27years) residing in Olmsted County, MN on December 31, 2012 (n=36,223). We compared age at vaccine initiation between individuals who successfully completed both 2 and 3 doses of the vaccination series on-time (before age 13.5 or 15.0years) using multivariate logistic regression. On-time completion of both 2 and 3 doses of the vaccine series by age 13.5 or 15.0years was significantly associated with initiation at 9 to 10years as compared to 11 to 12years after adjusting for sex, race, insurance status, frequent health care visits, and year of first vaccination (all p<.01). Interventions focused on beginning the vaccination series at 9 to 10years of age may result in higher rates of timely series completion.

Keywords: Immunization; Immunization programs; Papillomavirus vaccines, vaccination; Patient acceptance of health care; Patient compliance.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Age Factors
Child
Female
Humans
Immunization Programs*
Male
Minnesota
Papillomavirus Infections / prevention & control
Papillomavirus Vaccines / administration & dosage*
Patient Acceptance of Health Care
Vaccination / methods*

Substances

Papillomavirus Vaccines

Grants and funding

R01 AG034676/AG/NIA NIH HHS/United States