Detection of a Novel gyrB Mutation Associated With Fluoroquinolone-Nonsusceptible Salmonella enterica serovar Typhimurium Isolated From a Bloodstream Infection in Ghana

Clin Infect Dis. 2016 Mar 15:62 Suppl 1:S47-9. doi: 10.1093/cid/civ790.

Abstract

A multidrug-resistant Salmonella enterica serovar Typhimurium with reduced susceptibility to ciprofloxacin was isolated from the blood of a hospitalized child in Ghana. DNA sequencing identified a novel gyrB mutation at codon 466 (Glu466Asp). An increase in fluoroquinolone susceptibility after the introduction of a wild-type gyrB(+) allele demonstrated that the gyrB466 mutation had a direct effect on fluoroquinolone susceptibility.

Keywords: Typhimurium; fluoroquinolone; gyrB; resistance.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacteremia / microbiology*
  • Bacterial Proteins / genetics*
  • DNA Gyrase / genetics*
  • Drug Resistance, Bacterial / genetics*
  • Female
  • Fluoroquinolones / pharmacology*
  • Humans
  • Infant
  • Mutation / genetics
  • Salmonella Infections / microbiology*
  • Salmonella typhimurium* / drug effects
  • Salmonella typhimurium* / genetics

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Fluoroquinolones
  • DNA Gyrase