Translational Research for Tuberculosis Elimination: Priorities, Challenges, and Actions

Christian Lienhardt; Knut Lönnroth; Dick Menzies; Manica Balasegaram; Jeremiah Chakaya; Frank Cobelens; Jennifer Cohn; Claudia M Denkinger; Thomas G Evans; Gunilla Källenius; Gilla Kaplan; Ajay M V Kumar; Line Matthiessen; Charles S Mgone; Valerie Mizrahi; Ya-Diul Mukadi; Viet Nhung Nguyen; Anders Nordström; Christine F Sizemore; Melvin Spigelman; S Bertel Squire; Soumya Swaminathan; Paul D Van Helden; Alimuddin Zumla; Karin Weyer; Diana Weil; Mario Raviglione

doi:10.1371/journal.pmed.1001965

Translational Research for Tuberculosis Elimination: Priorities, Challenges, and Actions

PLoS Med. 2016 Mar 2;13(3):e1001965. doi: 10.1371/journal.pmed.1001965. eCollection 2016 Mar.

Authors

Christian Lienhardt¹, Knut Lönnroth¹, Dick Menzies², Manica Balasegaram³, Jeremiah Chakaya⁴, Frank Cobelens⁵, Jennifer Cohn³, Claudia M Denkinger⁶, Thomas G Evans⁷, Gunilla Källenius⁸, Gilla Kaplan⁹, Ajay M V Kumar¹⁰, Line Matthiessen¹¹, Charles S Mgone¹², Valerie Mizrahi¹³, Ya-Diul Mukadi¹⁴, Viet Nhung Nguyen¹⁵, Anders Nordström¹⁶, Christine F Sizemore¹⁷, Melvin Spigelman¹⁸, S Bertel Squire¹⁹, Soumya Swaminathan²⁰, Paul D Van Helden²¹, Alimuddin Zumla²², Karin Weyer¹, Diana Weil¹, Mario Raviglione¹

Affiliations

¹ World Health Organisation, Geneva, Switzerland.
² Montreal Chest Institute, McGill University, Montreal, Canada.
³ Access Campaign, Médecins Sans Frontières, Geneva, Switzerland.
⁴ Centre for Respiratory Diseases Research, Kenya Medical Research Institute (KEMRI), Nairobi, Kenya.
⁵ Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
⁶ FIND Diagnostics, Geneva, Switzerland.
⁷ Aeras, Rockville, Maryland, United States of America.
⁸ Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden.
⁹ Bill & Melinda Gates Foundation, Seattle, Washington, United States of America.
¹⁰ International Union Against Tuberculosis and Lung Disease, South-East Asia Regional Office, New Delhi, India.
¹¹ DG Research & Innovation, European Commission, Brussels, Belgium.
¹² The European & Developing Countries Clinical Trials Partnership (EDCTP), The Hague, The Netherlands.
¹³ Institute of Infectious Disease & Molecular Medicine, University of Cape Town, Cape Town, South Africa.
¹⁴ USAID, Washington, D.C., United States of America.
¹⁵ National TB Programme, National Lung Hospital, Hanoi, Viet Nam.
¹⁶ Ambassador for Global Health, Ministry for Foreign Affairs, Stockholm, Sweden.
¹⁷ Tuberculosis, Leprosy and other Mycobacterial Diseases Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America.
¹⁸ Global Alliance for TB Drug Development, New York, New York, United States of America.
¹⁹ Centre for Applied Health Research & Delivery, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
²⁰ National Institute for Research in Tuberculosis (NIRT), Indian Council of Medical Research, Chennai, India.
²¹ DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
²² Division of Infection and Immunity, University College London Medical School, London, United Kingdom.

Abstract

Christian Lienhardt and colleagues describe the research efforts needed to end the global tuberculosis epidemic by 2035.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Antitubercular Agents / therapeutic use*
Disease Eradication*
Drug Discovery
Global Health*
Health Services Accessibility*
Humans
Latent Tuberculosis / drug therapy*
Research*
Translational Research, Biomedical
Tuberculosis / prevention & control*
Tuberculosis Vaccines / therapeutic use*
World Health Organization

Substances

Antitubercular Agents
Tuberculosis Vaccines

Grants and funding

001/WHO_/World Health Organization/International