Sweet Relief: Reprogramming Gastric Endocrine Cells to Make Insulin

Heather A McCauley; James M Wells

doi:10.1016/j.stem.2016.02.009

Sweet Relief: Reprogramming Gastric Endocrine Cells to Make Insulin

Cell Stem Cell. 2016 Mar 3;18(3):295-7. doi: 10.1016/j.stem.2016.02.009.

Authors

Heather A McCauley¹, James M Wells²

Affiliations

¹ Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
² Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA; Division of Endocrinology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. Electronic address: [email protected].

PMID: 26942844
DOI: 10.1016/j.stem.2016.02.009

Abstract

Two promising approaches toward a cell-based cure for diabetes are the directed differentiation of pluripotent stem cells or lineage reprogramming of other cell types to generate beta cells. In this issue of Cell Stem Cell, Ariyachet et al. (2016) reprogrammed gastric endocrine cells to generate a renewable source of insulin-producing cells.

Publication types

Comment

MeSH terms

Cell Differentiation*
Cellular Reprogramming
Humans
Insulin / metabolism*
Insulin-Secreting Cells / cytology
Pluripotent Stem Cells / cytology

Substances

Insulin