Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms

Haematologica. 2016 Jun;101(6):e232-6. doi: 10.3324/haematol.2015.139527. Epub 2016 Mar 4.

¹ Department of Medicine, University of Chicago, Chicago, IL, USA [email protected].
² Department of Medicine, and University of Illinois Cancer Center, University of Illinois at Chicago, Chicago, IL, USA.
³ Department of Medicine, University of Chicago, Chicago, IL, USA.
⁴ Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
⁵ Department of Public Health Sciences, University of Chicago, Chicago, IL, USA University of Chicago Medicine Comprehensive Cancer Center, Chicago, IL, USA.
⁶ University of Chicago Medicine Comprehensive Cancer Center, Chicago, IL, USA Department of Pathology, University of Chicago, Chicago, IL, USA.
⁷ Department of Biochemistry and Molecular Genetics, Northwestern University Feinburg School of Medicine, Chicago, IL, USA.
⁸ University of Chicago Medicine Comprehensive Cancer Center, Chicago, IL, USA Departments of Pathology and Pediatrics, and Institute for Genomics and Systems Biology, University of Chicago, Chicago, IL, USA.
⁹ Department of Medicine, University of Chicago, Chicago, IL, USA University of Chicago Medicine Comprehensive Cancer Center, Chicago, IL, USA.

No abstract available

Keywords: Wnt pathway; del(5q); insertional mutagenesis; myeloid neoplasms; retroviral.

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