Light-Activated Hypoxia-Responsive Nanocarriers for Enhanced Anticancer Therapy

Adv Mater. 2016 May;28(17):3313-20. doi: 10.1002/adma.201505869. Epub 2016 Mar 7.

Abstract

A light-activated hypoxia-responsive conjugated polymer-based nanocarrier is developed for efficiently producing singlet oxygen ((1) O2 ) and inducing hypoxia to promote release of its cargoes in tumor cells, leading to enhanced antitumor efficacy. This dual-responsive nanocarrier provides an innovative design guideline for enhancing traditional photodynamic therapeutic efficacy integrated with a controlled drug-release modality.

Keywords: conjugated polymers; drug delivery; hypoxia-responsive; nanomedicine; photodynamic therapy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Cell Hypoxia
  • Cell Survival / drug effects
  • Doxorubicin / chemistry
  • Doxorubicin / pharmacology
  • Doxorubicin / therapeutic use
  • Drug Carriers / chemistry*
  • HeLa Cells
  • Humans
  • Hydrogen-Ion Concentration
  • Light*
  • Mice
  • Mice, Nude
  • Microscopy, Confocal
  • Microscopy, Electron, Transmission
  • Nanoparticles / chemistry*
  • Neoplasms / diagnostic imaging
  • Neoplasms / drug therapy
  • Neoplasms / pathology
  • Optical Imaging
  • Polyvinyl Alcohol / chemistry
  • Singlet Oxygen / chemistry
  • Singlet Oxygen / metabolism
  • Transplantation, Heterologous

Substances

  • Antineoplastic Agents
  • Drug Carriers
  • Singlet Oxygen
  • Doxorubicin
  • Polyvinyl Alcohol