Abstract
Despite the broad anti-microbial and anti-inflammatory properties of silver nanoparticles (AgNPs), their use in bioengineered corneal replacements or bandage contact lenses has been hindered due to their intense yellow coloration. In this communication, we report the development of a new strategy to pre-stabilize and incorporate AgNPs with different colours into collagen matrices for fabrication of corneal implants and lenses, and assessed their in vitro and in vivo activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Infective Agents / administration & dosage*
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Antimicrobial Cationic Peptides / chemistry
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Biocompatible Materials
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Cathelicidins
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Collagen / chemistry
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Cornea / surgery*
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Corneal Transplantation / instrumentation*
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Corneal Transplantation / methods
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Hydrogels / chemistry
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Interleukin-6 / metabolism
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Lens, Crystalline / surgery
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Materials Testing
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Metal Nanoparticles / chemistry*
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Mice
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Nanomedicine / methods
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Regenerative Medicine / methods*
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Silver / chemistry*
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Stress, Mechanical
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Tensile Strength
Substances
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Anti-Infective Agents
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Antimicrobial Cationic Peptides
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Biocompatible Materials
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Hydrogels
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Interleukin-6
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Silver
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Collagen
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Cathelicidins