Keywords: AF, atrial fibrillation; ATP, antitachycardia pacing; Bradycardia mode and rate; CI, confidence interval; CL, cycle length; CRT, cardiac resynchronization therapy; CRT-D, cardiac resynchronization therapy–defibrillator; DT, defibrillation testing; Defibrillation testing; EEG, electroencephalography; EGM, electrogram; HF, heart failure; HR, hazard ratio; ICD, implantable cardioverter-defibrillator; Implantable cardioverter-defibrillator; LV, left ventricle; LVEF, left ventricular ejection fraction; MI, myocardial infarction; MVP, managed ventricular pacing; NCDR, National Cardiovascular Data Registry; NYHA, New York Heart Association; OR, odds ratio; PEA, peak endocardial acceleration; PVC, premature ventricular contraction; Programming; RCT, randomized clinical trial; RV, right ventricle; S-ICD, subcutaneous implantable cardioverter-defibrillator; SCD, sudden cardiac death; SVT, supraventricular tachycardia; TIA, transient ischemic attack; Tachycardia detection; Tachycardia therapy; VF, ventricular fibrillation; VT, ventricular tachycardia (Heart Rhythm 2015;0:1–37); aCRT, adaptive cardiac resynchronization therapy.