Abstract
Efavirenz now forms part of many antiretroviral regimens in low and middle-income countries. Efavirenz-related drug-induced liver injury is not well characterized but is thought to occur less frequently than with nevirapine. We describe our observation of three defined clinicopathological patterns of injury, one of which, submassive necrosis, is associated with significant morbidity and mortality. A high baseline CD4, younger age and possibly female gender, predicts for the injury.
MeSH terms
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Adult
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Alkynes
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Benzoxazines / administration & dosage
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Benzoxazines / adverse effects*
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Chemical and Drug Induced Liver Injury / epidemiology*
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Chemical and Drug Induced Liver Injury / mortality
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Chemical and Drug Induced Liver Injury / pathology*
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Cyclopropanes
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Female
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HIV Infections / complications*
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HIV Infections / drug therapy*
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Humans
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Male
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Pregnancy
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Prospective Studies
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Retrospective Studies
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Reverse Transcriptase Inhibitors / administration & dosage
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Reverse Transcriptase Inhibitors / adverse effects*
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Risk Factors
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South Africa
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Survival Analysis
Substances
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Alkynes
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Benzoxazines
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Cyclopropanes
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Reverse Transcriptase Inhibitors
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efavirenz