Identification of virulence factors and antibiotic resistance markers using bacterial genomics

Future Microbiol. 2016;11(3):455-66. doi: 10.2217/fmb.15.149. Epub 2016 Mar 14.

Abstract

In recent years, the number of multidrug-resistant bacteria has increased rapidly and several epidemics were signaled in different regions of the world. Faced with this situation that presents a major global public health concern, the development and the use of new and rapid technologies is more than urgent. The use of the next-generation sequencing platforms by microbiologists and infectious disease specialists has allowed great progress in the medical field. Here, we review the usefulness of whole-genome sequencing for the detection of virulence and antibiotic resistance associated genes.

Keywords: antibiotic resistance; bacteria; virulence; whole-genome sequencing.

Publication types

  • Review

MeSH terms

  • Bacteria / drug effects
  • Bacteria / genetics*
  • Bacteria / pathogenicity
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Genome, Bacterial*
  • Genomics*
  • High-Throughput Nucleotide Sequencing / methods
  • Humans
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
  • Virulence / genetics
  • Virulence Factors / genetics*

Substances

  • Virulence Factors