Abstract
Primary cutaneous aspergillosis is rare in premature infants. It requires combined medical and surgical strategies. Liposomal amphotericin B is recommended as first-line therapy, but salvage regimens with others antifungal agents, such as voriconazole, have been reported. Voriconazole's pharmacodynamics is unknown in this population. We report a case of severe toxicity to voriconazole in a preterm patient with primary cutaneous aspergillosis.
MeSH terms
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Antifungal Agents / administration & dosage
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Antifungal Agents / adverse effects*
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Aspergillosis / drug therapy*
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Dermatomycoses / drug therapy*
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Drug-Related Side Effects and Adverse Reactions / diagnosis*
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Drug-Related Side Effects and Adverse Reactions / pathology*
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Fatal Outcome
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Humans
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Infant, Newborn
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Infant, Premature
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Male
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Multiple Organ Failure
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Voriconazole / administration & dosage
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Voriconazole / adverse effects*
Substances
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Antifungal Agents
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Voriconazole