Abstract
Hypereosinophilic syndromes (HESs) are a group of disorders characterized by end-organ damage caused by eosinophilic infiltration. We present a patient with idiopathic HES with severe tricuspid and mitral regurgitation secondary to Loeffler's endocarditis. In addition to prednisone, imatinib therapy initially helped control the eosinophil count. However, successful long-term remission was achieved with hydroxyurea therapy.
Copyright © 2016 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.
MeSH terms
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Adult
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Bioprosthesis*
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Echocardiography / methods
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Fibrosis
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Genetic Testing / methods
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Heart Valve Prosthesis Implantation* / instrumentation
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Heart Valve Prosthesis Implantation* / methods
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Heart Ventricles / diagnostic imaging
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Heart Ventricles / pathology
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Humans
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Hypereosinophilic Syndrome* / diagnosis
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Hypereosinophilic Syndrome* / pathology
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Hypereosinophilic Syndrome* / physiopathology
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Hypereosinophilic Syndrome* / therapy
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Imatinib Mesylate / administration & dosage*
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Magnetic Resonance Imaging, Cine / methods
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Male
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Mitral Valve Insufficiency* / diagnosis
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Mitral Valve Insufficiency* / etiology
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Mitral Valve Insufficiency* / physiopathology
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Mitral Valve Insufficiency* / therapy
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Mitral Valve* / diagnostic imaging
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Mitral Valve* / surgery
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Papillary Muscles / pathology*
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Protein Kinase Inhibitors / administration & dosage
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Thrombosis / diagnosis
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Thrombosis / etiology
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Thrombosis / therapy
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Treatment Outcome
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Tricuspid Valve* / diagnostic imaging
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Tricuspid Valve* / surgery
Substances
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Protein Kinase Inhibitors
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Imatinib Mesylate