Abstract
Core-shell type 'nanoghosts' were synthesized with a drug-loaded biodegradable PLGA core and a monocyte cell membrane-derived shell. The nanoghosts were monodisperse with an average size <200 nm, and showed good serum stability for 120 h. Doxorubicin-loaded nanoghosts showed greater cellular uptake and cytotoxicity compared to non-coated nanoparticle controls in metastatic MCF-7 breast cancer cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Membrane* / chemistry
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Cell Membrane* / metabolism
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Cell Membrane* / ultrastructure
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Cell Survival / drug effects
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Diffusion
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Doxorubicin / administration & dosage
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Doxorubicin / pharmacokinetics
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Drug Delivery Systems / methods*
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Humans
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Lactic Acid / chemistry*
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MCF-7 Cells
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Monocytes / ultrastructure*
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Nanoparticles
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Neoplasms / pathology
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Neoplasms / therapy*
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Particle Size
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Polyglycolic Acid / chemistry*
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Polylactic Acid-Polyglycolic Acid Copolymer
Substances
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Polylactic Acid-Polyglycolic Acid Copolymer
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Polyglycolic Acid
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Lactic Acid
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Doxorubicin