We have studied the Kerr effect in silica microspheres and demonstrated compensation of the Kerr effect for transient optomechanically induced transparency (OMIT). Due to the Kerr effect of the temporal strong driving pulse, an asymmetric transparency dip is observed during the transient OMIT experiment when the laser frequency is locked at one mechanical frequency, ω(m), below the whispering gallery mode resonance using a weak locking pulse. For compensation of the Kerr effect, we lock the laser at a lower frequency and show the symmetric transparency window. These results are important for studying photon-phonon interconversion, especially in systems with strong driving power.