Genome sequencing and annotation of multidrug resistant Mycobacterium tuberculosis (MDR-TB) PR10 strain

Mohd Zakihalani A Halim; Mohammad Maaruf Jaafar; Lay Kek Teh; Mohamad Izwan Ismail; Lian Shien Lee; Yun Fong Ngeow; Norazmi Mohd Nor; Zainul Fadziruddin Zainuddin; Thean Hock Tang; Mohd Nazalan Mohd Najimudin; Mohd Zaki Salleh

doi:10.1016/j.gdata.2016.01.002

Genome sequencing and annotation of multidrug resistant Mycobacterium tuberculosis (MDR-TB) PR10 strain

Genom Data. 2016 Jan 9:7:245-6. doi: 10.1016/j.gdata.2016.01.002. eCollection 2016 Mar.

Affiliations

¹ Integrative Pharmacogenomics Institute (iPROMISE), Universiti Teknologi MARA (UiTM), Malaysia.
² Integrative Pharmacogenomics Institute (iPROMISE), Universiti Teknologi MARA (UiTM), Malaysia; Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Selangor, Malaysia.
³ Faculty of Medicine & Health Sciences, Universiti Tunku Abdul Rahman, Malaysia.
⁴ School of Health Sciences, Health Campus, Universiti Sains Malaysia, Malaysia; Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Malaysia.
⁵ School of Health Sciences, Health Campus, Universiti Sains Malaysia, Malaysia; Business and Technopreneur Development Division, Malaysian Technology Development Corporation (MTDC) Sdn. Bhd, Malaysia.
⁶ Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, Malaysia.
⁷ School of Biological Sciences, Universiti Sains Malaysia, Malaysia.

Abstract

Here, we report the draft genome sequence and annotation of a multidrug resistant Mycobacterium tuberculosis strain PR10 (MDR-TB PR10) isolated from a patient diagnosed with tuberculosis. The size of the draft genome MDR-TB PR10 is 4.34 Mbp with 65.6% of G + C content and consists of 4637 predicted genes. The determinants were categorized by RAST into 400 subsystems with 4286 coding sequences and 50 RNAs. The whole genome shotgun project has been deposited at DDBJ/EMBL/GenBank under the accession number CP010968.

Keywords: Extrapulmonary; Genome; MDR; Mycobacterium tuberculosis.