Taking the Broad View on B Cell Affinity Maturation

Karlynn E Neu; Patrick C Wilson

doi:10.1016/j.immuni.2016.03.001

Taking the Broad View on B Cell Affinity Maturation

Immunity. 2016 Mar 15;44(3):518-520. doi: 10.1016/j.immuni.2016.03.001.

Authors

Karlynn E Neu¹, Patrick C Wilson²

Affiliations

¹ Committee on Immunology, The Knapp Center of Lupus and Immunology Research, The University of Chicago, Chicago, IL 60637, USA.
² Committee on Immunology, The Knapp Center of Lupus and Immunology Research, The University of Chicago, Chicago, IL 60637, USA; The Department of Medicine, The University of Chicago, Chicago, IL 60637, USA. Electronic address: [email protected].

PMID: 26982359
DOI: 10.1016/j.immuni.2016.03.001

Abstract

Germinal center (GC) responses are required for the generation of high-affinity antigen-specific B cells. Kuraoka et al. (2016) explore the importance of inter-clonal competition in GC affinity maturation through the use of complex immunizing antigens and discover an unexpected increase in clonal diversity over the course of the response.

Publication types

Comment

MeSH terms

Animals
B-Lymphocytes / physiology*
Clonal Selection, Antigen-Mediated*
Female
Germinal Center / immunology*
Humans
Receptors, Antigen, B-Cell / metabolism*

Substances

Receptors, Antigen, B-Cell

Abstract

Publication types

MeSH terms

Substances

Grants and funding