Atorvastatin inhibits miR-143 expression: A protective mechanism against oxidative stress in cardiomyocytes

Int J Cardiol. 2016 May 15:211:115-8. doi: 10.1016/j.ijcard.2016.02.141. Epub 2016 Mar 2.

Authors

Shanshan Tian¹, Wei Zhao¹, Di Yang¹, Yang Yu¹, Jiaqi Zou¹, Zhiyan Liu¹, Zhimin Du²

Affiliations

¹ Institute of Clinical Pharmacy, The Second Affiliated Hospital, Harbin Medical University, Harbin, China.
² Institute of Clinical Pharmacy, The Second Affiliated Hospital, Harbin Medical University, Harbin, China; The University Key Laboratory of Drug Research (The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, China. Electronic address: [email protected].

PMID: 26995052
DOI: 10.1016/j.ijcard.2016.02.141

No abstract available

Keywords: Apoptosis; Atorvastatin; Oxidative stress; miR-143.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Animals, Newborn
Atorvastatin / pharmacology*
Cardiotonic Agents / pharmacology*
Cells, Cultured
Gene Expression Regulation
Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology
MicroRNAs / antagonists & inhibitors*
MicroRNAs / biosynthesis*
MicroRNAs / genetics
Myocytes, Cardiac / drug effects
Myocytes, Cardiac / metabolism*
Oxidative Stress / drug effects
Oxidative Stress / physiology*
Rats

Substances

Cardiotonic Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
MIRN143 microRNA, rat
MicroRNAs
Atorvastatin