Overview of Transgenic Glioblastoma and Oligoastrocytoma CNS Models and Their Utility in Drug Discovery

Fuyi Chen; Albert Becker; Joseph LoTurco

doi:10.1002/0471141755.ph1437s72

Overview of Transgenic Glioblastoma and Oligoastrocytoma CNS Models and Their Utility in Drug Discovery

Curr Protoc Pharmacol. 2016 Mar 18:72:14.37.1-14.37.12. doi: 10.1002/0471141755.ph1437s72.

Authors

Fuyi Chen^{1

2}, Albert Becker³, Joseph LoTurco¹

Affiliations

¹ Department of Physiology and Neurobiology, University of Connecticut, Storrs, Conn.
² Current address: Department of Neurology, Yale School of Medicine, New Haven, Conn.
³ Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany.

Abstract

Many animal models have been developed to investigate the sources of central nervous system (CNS) tumor heterogeneity. Reviewed in this unit is a recently developed CNS tumor model using the piggyBac transposon system delivered by in utero electroporation, in which sources of tumor heterogeneity can be conveniently studied. Their applications for studying CNS tumors and drug discovery are also reviewed. © 2016 by John Wiley & Sons, Inc.

Keywords: anaplastic oligoastrocytoma; atypical teratoid rhabdoid tumor; central nervous system; glioblastoma multiforme; in utero electroporation; piggyBac transposon; tumor heterogeneity.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Animals, Genetically Modified
Astrocytoma / drug therapy*
Central Nervous System / drug effects*
Disease Models, Animal*
Drug Discovery / methods*
Glioblastoma / drug therapy*
Rats, Wistar

Abstract

Publication types

MeSH terms

Grants and funding