Abstract
A new controlled release system was developed by loading a dual-functional peptide (DFP) on a mesoporous silica material. One-pot synthesis produced a DFP that was stimuli responsive, releasing a therapeutic peptide by protease cleavage. The design provides new steps towards smart biomaterials.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Bacteria / enzymology
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Collagenases / metabolism
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Delayed-Action Preparations / chemistry*
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Delayed-Action Preparations / metabolism
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Porosity
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Silicon Dioxide / chemistry*
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Silicon Dioxide / metabolism
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alpha-MSH / administration & dosage*
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alpha-MSH / chemistry
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alpha-MSH / metabolism
Substances
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Delayed-Action Preparations
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alpha-MSH
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Silicon Dioxide
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Collagenases