Patterns and Time Dependence of Unspecific Enhancement in Postoperative Magnetic Resonance Imaging After Glioblastoma Resection

World Neurosurg. 2016 Jun:90:440-447. doi: 10.1016/j.wneu.2016.03.031. Epub 2016 Mar 18.

Abstract

Objective: Postoperative magnetic resonance imaging (MRI) is recommended soon after glioma surgery to avoid reactive nonneoplastic contrast enhancement indistinguishable from tumor. The purpose of this study was to analyze these patterns of postoperative contrast enhancement at 3 T to define the optimal time frame for postoperative MRI.

Methods: MRI for 206 glioblastoma surgeries in 173 patients who underwent pre- and postoperative and at least 1 follow-up 3T MRI for each surgery were analyzed retrospectively. Postoperative MRI was assessed in consensus by 2 neuroradiologists, blinded to the time after surgery. Postoperative contrast enhancement marginal to the resection cavity was analyzed and classified as vascular, linear, or nodular. The cause of the contrast enhancement (ie, reactive vs. tumor) was assessed by comparing pre-, postoperative, and follow-up MRI.

Results: Within 45 hours after surgery, reactive enhancement appeared in 17.9% of cases. After 45 hours, the fraction of reactive changes increased to 34.1%. Linear enhancement was more often reactive (66.1%, 39/59 cases), whereas nodular enhancement was mainly residual tumor (93.2%, 68/73 cases). Specificity of nodular enhancement was high for tumor recurrence/tumor progression (91.5%).

Conclusions: To avoid an increasing number of MRIs with reactive contrast enhancement, postoperative MRI at 3 T should be performed within 45 hours after surgery. However, reactive contrast enhancement can occur at all time points. In these cases, the pattern of the contrast enhancement may help to differentiate its cause.

Keywords: 3 Tesla; Early postoperative enhancement; Glioblastoma; Postoperative MRI.

MeSH terms

  • Brain / diagnostic imaging
  • Brain / surgery
  • Brain Neoplasms / diagnostic imaging*
  • Brain Neoplasms / surgery*
  • Contrast Media
  • Follow-Up Studies
  • Gadolinium DTPA
  • Glioblastoma / diagnostic imaging*
  • Glioblastoma / surgery*
  • Humans
  • Magnetic Resonance Imaging* / methods
  • Neoplasm Recurrence, Local / diagnostic imaging
  • Neurosurgical Procedures
  • Postoperative Care* / methods
  • Retrospective Studies
  • Time Factors

Substances

  • Contrast Media
  • Gadolinium DTPA