How drug resistance takes shape

Elife. 2016 Mar 24:5:e14973. doi: 10.7554/eLife.14973.

Abstract

Mutations in a hormone receptor can lead to therapeutic resistance by making it less able to bind and respond to hormone blocking drugs and by making it active, even when the hormome is not present.

Keywords: acquired drug resistance; biophysics; breast cancer; estrogen receptor alpha; hormone; human; human biology; medicine; selective estrogen receptor modulators; somatic mutation; structural biology.

Publication types

  • Comment

MeSH terms

  • Breast Neoplasms / drug therapy
  • Drug Resistance, Neoplasm / drug effects*
  • Humans
  • Receptors, Estrogen / metabolism
  • Selective Estrogen Receptor Modulators / pharmacology*

Substances

  • Receptors, Estrogen
  • Selective Estrogen Receptor Modulators