Abstract
A very rare case of acetylsulfapyridine nephrolithiasis is presented in a 54-year-old female patient who had been prescribed sulfasalazine (6 x 500 mg/day) because of psoriatic arthritis for the last 9 years. The patient's renal function was only slightly impaired. Reflectance infrared spectroscopy and gas chromatography-mass spectrometry allowed the identification of the chemical nature of the stone. As acetylsulfapyridine is a metabolite of sulfasalazine, administration of the latter drug was the cause of the nephrolithiasis.
MeSH terms
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
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Anti-Inflammatory Agents, Non-Steroidal / blood
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Arthritis, Psoriatic / drug therapy*
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Biotransformation
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Female
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Gas Chromatography-Mass Spectrometry
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Humans
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Kidney Calculi / blood
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Kidney Calculi / chemically induced*
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Kidney Calculi / diagnosis
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Kidney Calculi / therapy
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Middle Aged
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Spectrophotometry, Infrared
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Sulfapyridine / adverse effects
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Sulfapyridine / analogs & derivatives*
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Sulfapyridine / blood
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Sulfasalazine / adverse effects*
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Sulfasalazine / blood
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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N-acetylsulfapyridine
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Sulfasalazine
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Sulfapyridine