Rs1914663 of SFTPA 1 gene is associated with pediatric tuberculosis in Han Chinese population

Infect Genet Evol. 2016 Jul:41:16-20. doi: 10.1016/j.meegid.2016.03.018. Epub 2016 Mar 21.

Abstract

Surfactant protein A (SP-A), a part of the innate immune system of the lung, performs a vital role in the host defense against Mycobacterium tuberculosis (MTB) infection. In order to investigate the relationship between SFTPA polymorphism variations and Tuberculosis (TB) in a Chinese pediatric group, we conducted a case-control study using single-nucleotide polymorphism (SNP) analysis. Significant difference of the allelic distribution of rs1914663 in SFTPA gene was observed between TB group and control group and, T allele of rs1914663 was associated with increased risk for TB (control vs.

Tb, or: 1.42, 95% CI: 1.10-1.81, P=0.005). In addition, the TC+TT genotype of rs1914663 was higher in PTB and non-severe TB than that in controls. The haplotype comprising rs17881720-A and rs17879335-G was a resistance factor while the haplotype comprising rs1914663-T and rs1059225-G was found to be a susceptibility factor to TB. Using a case-control study, we identified a genetic polymorphism in the SFTPA that regulates host susceptibility to pediatric TB in the Han Chinese population.

Keywords: Genetic factors; Pediatric tuberculosis; SFTPA; Single nucleotide polymorphisms.

MeSH terms

  • Alleles
  • Asian People
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Female
  • Gene Expression
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Haplotypes
  • Humans
  • Male
  • Mycobacterium tuberculosis / growth & development
  • Polymorphism, Single Nucleotide*
  • Pulmonary Surfactant-Associated Protein A / genetics*
  • Risk
  • Severity of Illness Index
  • Tuberculosis / ethnology
  • Tuberculosis / genetics*
  • Tuberculosis / microbiology

Substances

  • Pulmonary Surfactant-Associated Protein A
  • SFTPA1 protein, human