Transient monosomy 7 in a chronic myelogenous leukemia patient during nilotinib therapy: a case report

Majd D Jawad; Ronald S Go; Rhett P Ketterling; Kebede H Begna; Kaaren K Reichard; Min Shi

doi:10.1002/ccr3.506

Transient monosomy 7 in a chronic myelogenous leukemia patient during nilotinib therapy: a case report

Clin Case Rep. 2016 Feb 8;4(3):282-6. doi: 10.1002/ccr3.506. eCollection 2016 Mar.

Authors

Majd D Jawad¹, Ronald S Go¹, Rhett P Ketterling², Kebede H Begna¹, Kaaren K Reichard³, Min Shi³

Affiliations

¹ Division of Hematology Mayo Clinic Rochester Minnesota.
² Division of Laboratory Genetics Mayo Clinic Rochester Minnesota.
³ Division of Hematopathology Mayo Clinic Rochester Minnesota.

Abstract

Tyrosine kinase inhibitor treated chronic myelogenous leukemia patients with monosomy 7 arising in Philadelphia chromosome negative (Ph-) cells tend to evolve into MDS/AML. However, monosomy 7 in Ph- cells can be a transient finding, and it is not an absolute indication of the emergence of a new myeloid malignancy.

Keywords: chronic myelogenous leukemia; monosomy 7.

Publication types

Case Reports