Gasometric titration for dimethylaluminum chloride analysis

Lin Wang; Peter Maligres; Kyle Eckenroad; Bryon Simmons

doi:10.1016/j.jpba.2016.03.022

Gasometric titration for dimethylaluminum chloride analysis

J Pharm Biomed Anal. 2016 Jun 5:125:110-3. doi: 10.1016/j.jpba.2016.03.022. Epub 2016 Mar 14.

Authors

Lin Wang¹, Peter Maligres², Kyle Eckenroad³, Bryon Simmons⁴

Affiliations

¹ Analytical Chemistry, Merck, Rahway, NJ 07065, USA. Electronic address: [email protected].
² Process Chemistry, Merck, Rahway, NJ 07065, USA. Electronic address: [email protected].
³ Analytical Chemistry, Merck, Rahway, NJ 07065, USA.
⁴ Process Chemistry, Merck, Rahway, NJ 07065, USA.

PMID: 27017569
DOI: 10.1016/j.jpba.2016.03.022

Abstract

A gasometric titration method was developed to quantitate active alkylaluminum content in dimethylaluminum chloride solution to perform the stoichiometry calculation for the reaction charge. The procedure was reproducible with good precision, and the results showed good correlation with ICP-MS method. The gasometric titration is a simple, inexpensive alternative to analysis via ICP-MS which provides more selective analysis of methylaluminum species without the need for inertion.

Keywords: Alkylaluminum; Dimethylaluminum chloride; Gasometric titration; ICP-MS; Methane.

MeSH terms

Organometallic Compounds / analysis*
Reproducibility of Results
Spectrum Analysis / methods*

Substances

Organometallic Compounds
dimethylaluminum chloride