Abstract
Polyelectrolyte multilayer (PEM) capsules are promising candidates for many kinds of cancer detection and treatment but are usually intended to deliver cargo to specific sites or to destroy cancer cells based on photothermal effects from the outside. In this publication we prove that it is possible to kill cancer cells from the inside based on phagocytosed PEM capsules. In addition we show how to open the cells and bring the PEM capsules to the surface of cancer cells based on photothermal effects and rapid evaporation of water. Diffusion-based temperature determinations of the photothermal effect up to the evaporation temperature of water are presented.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adsorption
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / radiation effects
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Capsules
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Carbocyanines / chemistry
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Cell Line, Tumor
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Cell Membrane / chemistry*
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Fluorescent Dyes / chemistry
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Gold / chemistry*
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Hot Temperature
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Humans
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Infrared Rays
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Metal Nanoparticles / chemistry*
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Metal Nanoparticles / radiation effects
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Monocytes / chemistry*
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Phagocytosis
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Phototherapy
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Polyamines / chemistry
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Polyelectrolytes / chemistry*
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Polystyrenes / chemistry
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Propidium / chemistry
Substances
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1,1'-dioctadecyl-3,3,3',3'-tetramethylindodicarbocyanine
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Antineoplastic Agents
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Capsules
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Carbocyanines
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Fluorescent Dyes
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Polyamines
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Polyelectrolytes
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Polystyrenes
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polyallylamine
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Propidium
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polystyrene sulfonic acid
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Gold