Gadolinium-Decorated Silica Microspheres as Redox-Responsive MRI Probes for Applications in Cell Therapy Follow-Up

Chemistry. 2016 Jun 1;22(23):7716-20. doi: 10.1002/chem.201600962. Epub 2016 Apr 26.

Abstract

The redox microenvironment within a cell graft can be considered as an indicator to assess whether the graft is metabolically active or hypoxic. We present a redox-responsive MRI probe based on porous silica microparticles whose surface has been decorated with a Gd-chelate through a disulphide bridge. Such microparticles are designed to be interspersed with therapeutic cells within a biocompatible hydrogel. The onset of reducing conditions within the hydrogel is paralleled by an increased clearance of Gd, that can be detected by MRI.

Keywords: cellular imaging; gadolinium; magnetic resonance imaging; redox-responsive; silica microspheres.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials / chemistry
  • Biocompatible Materials / pharmacology
  • Cell Line
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Cell- and Tissue-Based Therapy
  • Collagen / chemistry
  • Contrast Media / chemistry*
  • Disulfides / chemistry
  • Gadolinium / chemistry*
  • Humans
  • Hyaluronic Acid / chemistry
  • Hydrogels / chemistry
  • Magnetic Resonance Imaging*
  • Microspheres*
  • Oxidation-Reduction
  • Porosity
  • Silicon Dioxide / chemistry*
  • Surface Properties

Substances

  • Biocompatible Materials
  • Contrast Media
  • Disulfides
  • Hydrogels
  • Silicon Dioxide
  • Hyaluronic Acid
  • Collagen
  • Gadolinium