Sickle Cell Disease in Sub-Saharan Africa

Hematol Oncol Clin North Am. 2016 Apr;30(2):343-58. doi: 10.1016/j.hoc.2015.11.005. Epub 2016 Jan 28.

Abstract

In Africa, at least 240,000 children are born each year with sickle cell disease. Historically, in the absence of newborn screening and appropriate treatment, most such children died undiagnosed in early childhood. However, with increasing awareness of the condition and economic and epidemiologic transition, increasing numbers are surviving. Greater investments in basic and applied research in the African context, and increased sensitization or African ministries of health regarding the importance of this condition, could make a substantial difference to the lives and livelihoods of millions of people living with sickle cell disease on the continent and their families.

Keywords: Bacteremia; Children; Public health; Sickle cell disease; Sub-Saharan Africa.

Publication types

  • Review

MeSH terms

  • Africa South of the Sahara / epidemiology
  • Age Factors
  • Anemia, Sickle Cell / diagnosis
  • Anemia, Sickle Cell / epidemiology*
  • Anemia, Sickle Cell / genetics
  • Anemia, Sickle Cell / therapy
  • Cause of Death
  • Comorbidity
  • Cost of Illness
  • Delivery of Health Care
  • Global Health
  • Humans
  • Mutation
  • beta-Globins / genetics

Substances

  • beta-Globins