State-of-the-Art Metabolic Toxicity Screening and Pathway Evaluation

Eli G Hvastkovs; James F Rusling

doi:10.1021/acs.analchem.5b04772

State-of-the-Art Metabolic Toxicity Screening and Pathway Evaluation

Anal Chem. 2016 May 3;88(9):4584-99. doi: 10.1021/acs.analchem.5b04772. Epub 2016 Apr 14.

Authors

Eli G Hvastkovs¹, James F Rusling^{2

3

4

5}

Affiliations

¹ Department of Chemistry, East Carolina University Greenville, North Carolina 27858, United States.
² Department of Chemistry, University of Connecticut , Storrs, Connecticut 06269, United States.
³ Department of Surgery and Neag Cancer Center, University of Connecticut Health Center , Farmington, Connecticut 06032, United States.
⁴ Institute of Material Science, University of Connecticut , Storrs, Connecticut 06269, United States.
⁵ School of Chemistry, National University of Ireland at Galway , Galway, Ireland.

Abstract

Routine in vitro bioassays and animal toxicity studies of drug and environmental chemical candidates fail to reveal toxicity in ∼30% of cases. This Feature article addresses research on new approaches to in vitro toxicity testing as well as our own efforts to produce high-throughput genotoxicity arrays and LC-MS/MS approaches to reveal possible chemical pathways of toxicity.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chromatography, High Pressure Liquid
Drug-Related Side Effects and Adverse Reactions
High-Throughput Screening Assays / methods*
Humans
Molecular Structure
Pharmaceutical Preparations
Tandem Mass Spectrometry
Toxicity Tests / methods*

Substances

Pharmaceutical Preparations

Grants and funding

R01 ES003154/ES/NIEHS NIH HHS/United States